Anti-cancer drug binding to DNA, AFM
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Anti-cancer drug binding to DNA, AFM
Drug-DNA complexes. Coloured atomic force micrograph (AFM) of plasmids (blue) of DNA (deoxyribonucleic acid) bound to the anti-cancer drug ditercalinium. This drug distorts the shape of DNA, which eventually causes the death of affected cells. Distorted regions are yellow here. Plasmids are loops of DNA found in some bacteria and yeast cells that exist separately from the cells chromosomal DNA. They are able to replicate and express their genes independently, and are widely used in genetic research and engineering. Atomic force microscopy produces an image by moving a sensitive tip over a surface. Magnification: x75, 000 at 6x6cm size
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6392495
© TORUNN BERGE/SCIENCE PHOTO LIBRARY
Anti Cancer Atomic Force Micrograph Binding Bio Technology Bioengineered Bioengineering Chemotherapy Circular Drug Drugs Effect Genetic Loop Loops Manufacture Microscopy Plasmid Production Strands Treatment Deoxyribonucleic Acid Genetics Unwinding
EDITORS COMMENTS
This print from Science Photo Library showcases the intricate interaction between an anti-cancer drug and DNA. In this coloured atomic force micrograph (AFM), we witness the binding of ditercalinium, a potent anti-cancer drug, to DNA strands. The drug's mechanism of action involves distorting the shape of DNA, leading to cell death in affected cells. The yellow regions in this image represent the distorted areas caused by ditercalinium binding. Additionally, we can observe plasmids - circular loops of DNA found in certain bacteria and yeast cells - depicted in blue. Plasmids exist independently from chromosomal DNA and possess the ability to replicate and express their genes autonomously. Atomic force microscopy is responsible for capturing this mesmerizing image by delicately maneuvering a sensitive tip over the surface. At a magnification level of x75,000 on a 6x6cm scale, this AFM technique allows us to delve into the microscopic world with incredible detail. These findings hold significant importance for genetic research and engineering as plasmids are widely utilized tools within these fields. Furthermore, understanding how drugs like ditercalinium interact with DNA provides valuable insights for chemotherapy treatments and bioengineering advancements. Science Photo Library has once again delivered an awe-inspiring visual representation that beautifully combines artistry with scientific discovery.
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