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Immunofluorescent LM of active macrophages
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Immunofluorescent LM of active macrophages
Active macrophages. Immunofluorescent light micrograph of active macrophage white blood cells producing cytokine proteins. The cells have multiple nuclei (blue). Vaults are red and TIA-1, a protein which stops cytokine overproduction, is yellow/green. Cytokines are released by one cell population in order to influence another. If too much cytokine has been made, TIA-1 stops its production by binding to the mRNA (messenger ribonucleic acid) that codes for it, forming stress bodies (yellow). These macrophages have been activated by exposure to a mock bacterial infection. Macrophages help to kill invading organisms. Magnification: x200 at 5x7cm size
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6421240
© NANCY KEDERSHA/SCIENCE PHOTO LIBRARY
Active Cytokine Defence Immune Immunofluores Immunology Infection Macrophage Macrophages System Cells Light Micrograph Vault
EDITORS COMMENTS
This print from Science Photo Library showcases the intricate world of active macrophages, a type of white blood cell that plays a crucial role in our immune system. The immunofluorescent light micrograph reveals the dynamic nature of these cells as they produce cytokine proteins, which are essential for intercellular communication and influencing other cell populations. The image displays multiple nuclei within the macrophages, depicted in a striking blue hue. Additionally, red vaults and yellow/green TIA-1 proteins are visible throughout. TIA-1 serves as an important regulator by preventing excessive cytokine production. When too much cytokine is present, TIA-1 binds to the mRNA responsible for its coding, forming stress bodies represented by vibrant yellow clusters. These particular macrophages have been activated through exposure to a simulated bacterial infection. As part of their defense mechanism, macrophages aid in eliminating invading organisms and maintaining overall immune health. At a magnification of x200 on a 5x7cm scale, this mesmerizing photograph offers us an up-close glimpse into the complex anatomy and functioning of our immune system's frontline defenders – macrophages. It highlights their vital role in orchestrating immune responses while shedding light on key molecular interactions involved in regulating cytokine production.
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