Sirtuin enzyme and p53, artwork C017 / 3658

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Sirtuin enzyme and p53, artwork C017 / 3658

Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (pink) bound to a p53 peptide (orange). Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases that are required for diverse biological processes, including transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilisation, and lifespan regulation. NAD is shown as a stick model (centre). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA

Science Photo Library features Science and Medical images including photos and illustrations

Media ID 9340363

© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Binding Bound Cell Cycle Complex Complexed Metabolic Metabolism Peptide Preventative Prevention Proteins Proteomics Regulation Regulator Secondary Structure Tertiary Structure Tumor Suppressor Tumour Suppressor Protein Biochemical Biochemistry Molecular Model Protein

EDITORS COMMENTS
This artwork, titled "Sirtuin Enzyme and p53" beautifully captures the intricate molecular dance between a sirtuin enzyme (Sir2) and a p53 peptide. In this computer-generated illustration, the Sir2 enzyme is depicted in a mesmerizing shade of pink, while the p53 peptide shines vibrantly in orange. Sir2 enzymes belong to a unique class of NAD (+)-dependent deacetylases that play crucial roles in various biological processes. They are involved in transcriptional silencing, apoptosis regulation (programmed cell death), fat mobilization, and even lifespan regulation. The central stick model represents NAD, which serves as an essential component for Sir2's function. On the other hand, p53 holds immense importance in multicellular organisms as it regulates the cell cycle and prevents damaged DNA from proliferating. This complexed binding between Sir2 and p53 showcases their biochemical interplay as regulators of cellular functions. The meticulous attention to detail highlights not only the structural aspects but also emphasizes key elements such as secondary structure and tertiary structure within these proteins. This artwork provides us with a glimpse into the fascinating world of proteomics by visualizing these vital molecules at work. Created by Ramon Andrade 3DCiencia/Science Photo Library, this print offers both aesthetic appeal and scientific insight into two significant players within cellular biology – Sirtuin enzymes and p53 peptides.

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