Tumour necrosis factor-alpha
Wall Art and Photo Gifts from Science Photo Library
Tumour necrosis factor-alpha
Tumour necrosis factor-alpha (TNF-alpha), computer model. This molecule is composed almost entirely of anti-parallel beta-sheets (blue). This protein generally exists as a trimer (a molecule consisting of 3 identical smaller molecules, seen here). It is released by white blood cells, mainly macrophages, during inflammatory immune responses, and acts as a signalling molecule. Its release is triggered by injury or bacterial endotoxins. One of its actions is to kill tumour cells, hence its name. TNF-alpha is also involved in a number of inflammatory diseases, including rheumatoid arthritis, psoriasis and Crohns disease
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6279499
© DR MARK J. WINTER/SCIENCE PHOTO LIBRARY
Computer Model Cytokine Defense Immune Response Immune System Psoriasis Rheumatoid Arthritis Structural Trimer Tumor Bio Chemistry Computer Artwork Molecular Protein
EDITORS COMMENTS
This print showcases a computer model of Tumour Necrosis Factor-alpha (TNF-alpha), an essential protein in the field of medicine and biochemistry. The intricate structure of TNF-alpha is predominantly composed of anti-parallel beta-sheets, beautifully depicted in shades of blue. In its natural form, this protein exists as a trimer, consisting of three identical smaller molecules interconnected. White blood cells, particularly macrophages, release TNF-alpha during inflammatory immune responses to act as a crucial signaling molecule. Triggered by injury or bacterial endotoxins, it plays a significant role in our body's defense mechanism. Notably named for one of its remarkable functions - killing tumour cells - TNF-alpha has proven invaluable in combating cancerous growths. However, beyond its tumor-killing abilities lie various implications in inflammatory diseases such as rheumatoid arthritis, psoriasis, and Crohn's disease. This multifaceted protein contributes to the pathogenesis and progression of these conditions. The visually stunning computer artwork offers us an insight into the structural complexity and significance behind TNF-alpha. Its molecular arrangement serves as a testament to the intricate workings within our immune system and highlights the vital role played by proteins like TNF-alpha in maintaining our overall health. This extraordinary image from Science Photo Library not only captures the beauty found within scientific research but also reminds us how far we have come in understanding complex biological processes that impact human well-being.
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