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Neurofibromatosis, a genetic disorder of the nervous system
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Neurofibromatosis, a genetic disorder of the nervous system
A genetic disorder of the nervous system, neurofibromatosis causes tumors to form on nerves throughout the body, including a type of tumor called an optic nerve glioma that can result in childhood blindness. The image was used to demonstrate the unique imaging capabilities of one of our newest (at the time) laser scanning microscopes and is of a wildtype (normal) mouse retina in the optic fiber layer. This layer is responsible for relaying information from the retina to the brain and was fluorescently stained to reveal the distribution of glial cells (green), DNA and RNA in the cell bodies of the retinal ganglion neurons (orange) and their optic nerve fibers (red), and actin in endothelial cells surrounding a prominent branching blood vessel (blue). By studying the microscopic structure of normal and diseased retina and optic nerves, we hope to better understand the altered biology of the tissues in these tumors with the prospects of developing therapeutic interventions
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Abundance Analysis Bacteria Biology Biomedical Biotechnology Blood Vessels Blue Branching Cell Cell Biology Cell Body Central Nervous System Condition Disorder Extreme Close Up Full Frame Genetic Green Growth Healthcare Medical Medicine Microbiology Nerve Nervous System Neuroscience Optic Nerves Orange Pathogen Research Tumor Actin Glia Glial Cells Glioma Homeostasis Neuroglia
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This print showcases the intricate world of neurofibromatosis, a genetic disorder that affects the nervous system. The image was captured using one of our cutting-edge laser scanning microscopes, highlighting its exceptional imaging capabilities. In this particular shot, we observe a wildtype (normal) mouse retina in the optic fiber layer - a crucial component responsible for transmitting visual information from the retina to the brain. To reveal the distribution of various cellular elements, fluorescent staining was employed. Glial cells are depicted in vibrant green hues, while DNA and RNA within retinal ganglion neurons' cell bodies appear in striking orange tones. Additionally, their optic nerve fibers exhibit a mesmerizing shade of red. The blue coloration emphasizes actin present in endothelial cells surrounding an imposing branching blood vessel within this complex network. By meticulously studying both healthy and diseased retinas and optic nerves at microscopic levels, our goal is to gain deeper insights into how these tumors alter biological processes. Through this exploration, we aim to unravel vital knowledge that could potentially pave the way for therapeutic interventions targeting neurofibromatosis-related complications such as childhood blindness caused by optic nerve gliomas.
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