Agonist Collection

Illustration of cell reaction to agonist drug (left) and to antagonist drug (right)

Varenicline smoking cessation drug, molecular model. This drug is a partial agonist of the nicotine receptor. Atoms are represented as spheres and are colour-coded: hydrogen (white)

Raloxifene osteoporosis drug molecule
Raloxifene osteoporosis drug, molecular model. This drug, marketed as Evista, is used to prevent osteoporosis in postmenopausal women

Zolpidem, sedative drug
Zolpidem sedative drug, molecular model. This drug, marketed under several brand names including Ambien and Stilnoct, is used for the short-term treatment of insomnia

Enclomifene infertility drug molecule
Enclomifene infertility drug, molecular model. The drug clomifene, used to treat infertility in women, is made up of two components, enclomifene (shown here) and zuclomifene

Zuclomifene infertility drug molecule
Zuclomifene infertility drug, molecular model. The drug clomifene, used to treat infertility in women, is made up of two components, enclomifene and zuclomifene (shown here)

TGN1412 drug molecule. Computer model showing the secondary structure of the drug TGN1412. This drug was shown to have serious side effects during a clinical trial in the UK in 2006 when it caused

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"Unlocking the Cell's Response: The Power Drugs" In the fascinating world of pharmacology, agonist drugs hold a key role in triggering cellular reactions. Through an intricate dance with receptors, these drugs can elicit specific responses within our bodies. Take a closer look at the illustration on the left, showcasing how an agonist drug interacts with cells. As it binds to its designated receptor site, a cascade of events is set into motion – like unlocking a door and activating various cellular pathways. This process leads to desired effects such as pain relief or mood elevation. Contrastingly, on the right side of this cross-section biomedical illustration lies an antagonist drug – acting as a roadblock rather than opening doors for cellular response. It competes with agonists for receptor sites but fails to trigger any significant reaction. One notable example is Varenicline, a smoking cessation drug that acts as an agonist by targeting nicotine receptors in our brain. By mimicking nicotine's effects without causing addiction or harmful consequences, Varenicline helps individuals overcome their tobacco dependence. Moving beyond smoking cessation aids, let us delve into cannabis-related compounds represented by molecular models here. Cannabidiol (CBD) stands out among them due to its non-psychoactive nature and potential therapeutic benefits ranging from anxiety reduction to pain management. Meanwhile, Tetrahydrocannabinol (THC), another molecule found in cannabis plants depicted multiple times here due to its significance in recreational marijuana use and medicinal applications alike. THC acts as both an agonist and antagonist depending on different receptor systems within our body. Shifting gears towards other medical realms, Raloxifene emerges as an osteoporosis drug molecule worth exploring further. Acting selectively as an estrogen receptor modulator (SERM), it exhibits both agonistic and antagonistic properties depending on target tissues – promoting bone health while inhibiting breast cancer cell growth simultaneously.