Fibrinogen Collection

Blood coagulation cascade, artwork C016 / 9873
Blood coagulation cascade. Artwork of the biochemical cascade of blood chemicals and proteins during blood clotting (coagulation). The blood vessel and its layered wall is at upper left

Blood vessel with platelets, white blood cells and red blood cells

Conceptual image of red blood cells with fibrin

Fibrinogen molecule C014 / 0473
Fibrinogen. Molecular model showing the structure of the blood clotting glycoprotein fibrinogen (factor I). The molecule consists of two sets of alpha (grey)

Integrin and fibrinogen complex molecule F006 / 9649
Integrin and fibrinogen complex. Molecular model of integrin alpha-II beta-3 complexed with fibrinogen. Integrin alpha-II beta-3 is a transmembrane protein found on platelets

Thrombin complexed with fibrinogen F006 / 9561
Thrombin complexed with fibrinogen, molecular model. The thrombin molecules (beige, right and left) are bound to the central part of the fibrinogen molecule (down centre)

Thrombin complexed with fibrinogen C015 / 7148
Thrombin complexed with fibrinogen, molecular model. The thrombin molecules (left and right, purple and green) are bound to the central part of the fibrinogen molecule (centre, multiple colours)

Thrombin complexed with fibrinogen C015 / 7149
Thrombin complexed with fibrinogen, molecular model. The thrombin molecules (left and right, brown and pink) are bound to the central part of the fibrinogen molecule (centre, multiple colours)

Fibrinogen molecule C014 / 0472
Fibrinogen. Molecular model showing the secondary structure of the blood clotting glycoprotein fibrinogen (factor I). The molecule consists of two sets of alpha (grey)

Fibrin strands, artwork
Fibrin strands. Computer artwork depicting a number of fibrin strands with their ends embedded in the membrane of a cell. Fibrin is composed of fibrinogen proteins

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Fibrinogen: A Pivotal Player in Blood Coagulation Cascade At the heart of the intricate blood coagulation process lies the protein fibrinogen. This glycoprotein, represented by the C014 / 0473 and C014 / 0472 images, circulates in the bloodstream as an inactive precursor. When injury occurs, fibrinogen interacts with platelets and white blood cells at the site of damage, initiating a cascade of events. The integrin and fibrinogen complex (F006 / 9649) plays a crucial role in this process, allowing fibrinogen to bind to the platelet surface. Thrombin, a key enzyme in coagulation, then complexes with fibrinogen (F006 / 9561, C015 / 7148, and C015 / 7149), catalyzing its conversion into fibrin monomers. These monomers polymerize into long, insoluble fibrin strands (artwork), forming a mesh that helps to plug the wound and prevent further blood loss. In summary, fibrinogen is an essential component of the blood coagulation system, transforming from an inactive precursor to an active participant in the formation of a stable clot. Its intricate interactions with platelets, white blood cells, and thrombin ultimately contribute to the body's ability to effectively stop bleeding and promote healing.