Rna Interference Collection

RNA-induced silencing complex F006 / 9586
RNA-induced silencing complex (RISC), molecular model. This complex consists of a bacterial argonaute protein (top) bound to a small interfering RNA (siRNA) molecule (red and blue)

RNA-induced silencing complex F006 / 9587
RNA-induced silencing complex (RISC), molecular model. This complex consists of a bacterial argonaute protein (top right) bound to a small interfering RNA (siRNA) molecule (red and blue)

RNA interference protein, molecular model F006 / 9589
RNA interference protein, molecular model. This RNA interference protein is also known as dicer. It is an RNAase enzyme that cleaves double-stranded RNA into short fragments called small interfering

RNA-induced silencing complex F006 / 9502
RNA-induced silencing complex (RISC), molecular model. This complex consists of a bacterial argonaute protein bound to a small interfering RNA (siRNA) molecule (red and blue)

RNA interference viral suppressor and RNA F006 / 9488
RNA interference viral suppressor and RNA. Molecular model of the p19 protein (yellow) from a Tombusvirus, suppressing a double-stranded, small interfering RNA (siRNA) molecule (red and blue)

RNA interference viral suppressor molecule. Computer model showing the molecular structure of the p21 protein from a beet yellow virus

RNA interference, computer artwork
RNA interference (RNAi) is a mechanism of gene expression involving double-stranded ribonucleic acid (RNA). Double-stranded RNA (or dsRNA), as is seen here

RNA-Induced Silencing Complex (RISC). Computer model showing the molecular structure of a bacterial argonaute protein (red) bound to a small interfering RNA (siRNA) molecule (green and purple)

RNA interference viral suppressor and RNA. Computer model showing the molecular structure of the p19 protein (pink, top) from a Tombusvirus, suppressing a double-stranded

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RNA interference (RNAi) is a powerful cellular mechanism that regulates gene expression and plays a crucial role in various biological processes. At the heart of this intricate process lies the RNA-induced silencing complex (RISC), which consists of small interfering RNAs (siRNAs) and proteins. The RISC, represented by F006 / 9586 and F006 / 9587, acts as a molecular machine capable of selectively degrading target messenger RNAs (mRNAs). This targeted degradation prevents the translation of specific genes into functional proteins, thereby effectively silencing their expression. Visualized through the molecular model F006 / 9589, RNA interference protein represents an essential component within RISC. It binds to siRNAs and guides them towards complementary mRNA sequences for destruction. The precise interaction between these molecules ensures accurate gene regulation. Intriguingly, viral infections have evolved mechanisms to counteract RNAi's defense system. The RNA interference viral suppressor depicted in F006 / 9488 cleverly inhibits RISC activity by binding to both siRNAs and mRNAs. By doing so, it hampers the efficiency of gene silencing mediated by RNAi. Understanding how viruses manipulate this process has significant implications for antiviral strategies. Scientists are actively studying these interactions using models such as F006 / 9502 to uncover new ways to combat viral infections effectively. Overall, RNA interference stands as an elegant regulatory mechanism orchestrated by the versatile RISC machinery. Its ability to modulate gene expression offers immense potential for therapeutic interventions against diseases ranging from cancer to genetic disorders.