Inhibiting Collection

Anaesthetic inhibiting an ion channel C015 / 6718
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Ricin A-chain, artwork C017 / 3653
Ricin A-chain. Computer artwork showing the enzymatically active A-chain from a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (seen here) and B (not shown)

Ricin molecule, artwork C017 / 3652
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3651
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3650
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin A-chain, artwork C017 / 3654
Ricin A-chain. Computer artwork showing the enzymatically active A-chain from a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (seen here) and B (not shown)

Ricin molecule, artwork C017 / 3649
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

HIV-1 protease and inhibitor F006 / 9773
HIV-1 protease and inhibitor. Molecular model of the enzyme HIV-1 protease (pink and blue ribbons) bound to an inhibitor molecule (centre)

Kinase inhibitor complex F006 / 9760
Kinase inhibitor complex. Molecular model of a leucettine kinase inhibitor bound to a serine threonine kinase protein

Flu virus surface protein and drug F006 / 9745
Flu virus surface protein and drug. Molecular model of the neuraminidase glycoprotein enzyme from on the surface of the influenza A (flu) virus bound to the drug zanamivir

HIV reverse transcription enzyme F006 / 9684
HIV reverse transcription enzyme. Molecular model of the reverse transcriptase enzyme found in HIV (the human immunodeficiency virus) bound to the inhibitor nevirapine

RNA interference viral suppressor and RNA F006 / 9488
RNA interference viral suppressor and RNA. Molecular model of the p19 protein (yellow) from a Tombusvirus, suppressing a double-stranded, small interfering RNA (siRNA) molecule (red and blue)

HIV reverse transcription enzyme F006 / 9385
HIV reverse transcription enzyme. Molecular model of the reverse transcriptase enzyme found in HIV (the human immunodeficiency virus) bound to the inhibitor nevirapine

Cholesterol producing enzyme and statin F006 / 9366
Cholesterol producing enzyme and statin. Computer model showing the molecular structure of HMG-CoA reductase (HMGCR) in complex with Atorvastatin

Beta secretase enzyme, molecular model F006 / 9333
Beta secretase enzyme. Molecular model of the enzyme beta secretase bound to an inhibitor molecule. Beta secretase is a membrane-associated aspartic protease

LAC repressor bound to DNA F006 / 9309
LAC repressor bound to DNA. Molecular model of a LAC (lactose) repressor molecule (pink and turquoise) interacting with bacterial DNA (deoxyribonucleic acid, red and blue)

Ribonuclease bound to inhibitor F006 / 9287
Ribonuclease bound to inhibitor, molecular model. Ribonuclease (RNase) is a type of nuclease that catalyses the degradation of RNA (ribonucleic acid)

Acetylcholine receptor-conotoxin complex. Molecular model showing alpha-conotoxin bound to a nicotinic acetlycholine receptor

Ricin molecule, artwork C017 / 3656
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3655
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3648
Ricin molecule Computer artwork showing the structure of a molecule of the toxic protein ricin (blue and yellow) with an active ribosome in the background

Bone morphogenetic protein complex, molecular model. Bone Morphogenetic Protein-7 (BMP-7, blue) in complex with the secreted antagonist Noggin (pink)

Beta secretase inhibitor, molecular model. The inhibitor molecule (centre, also shown in C015/1977) is bound to the beta secretase enzyme (partially seen)

Anaesthetic inhibiting an ion channel C015 / 6723
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres) bound to a pentameric ligand-gated ion channel (pLGIC, blue ribbons)

Anaesthetic inhibiting an ion channel C015 / 6722
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres) bound to a pentameric ligand-gated ion channel (pLGIC, blue ribbons)

Anaesthetic inhibiting an ion channel C015 / 6720
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey)

Anaesthetic inhibiting an ion channel C015 / 6721
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Anaesthetic inhibiting an ion channel C015 / 6719
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Beta secretase enzyme, molecular model C015 / 5277
Beta secretase enzyme. Molecular model of the enzyme beta secretase bound to an inhibitor molecule. Beta secretase is a membrane-associated aspartic protease

Tryptophan repressor bound to DNA C015 / 6243
Tryptophan repressor bound to DNA. Molecular model of the tryptophan (trp) repressor (grey and green, and orange and yellow, across bottom) bound to DNA (deoxyribonucleic) molecules (blue and orange)

Tryptophan repressor bound to DNA C015 / 6242
Tryptophan repressor bound to DNA. Molecular model of the tryptophan (trp) repressor (purple and green, and pink and beige, across bottom) bound to DNA (deoxyribonucleic) molecules (blue and orange)

Influenza inhibition mechanism, artwork C016 / 5794
Influenza inhibition mechanism. Artwork of the membrane of an influenza (flu) virus, showing a molecule of the drug zanamivir (space-filled sphere model)

Preventing cancer spreading, artwork C013 / 8816
Preventing cancer spreading, conceptual artwork. Cancer cells inside a geodesic cage, representing the prevention of metastasis - spreading to other tissues of the body

Angiogenesis inhibitors, conceptual image C013 / 7789
Angiogenesis inhibitors, conceptual image. Computer artwork showing a brick wall preventing new blood vessels from reaching a cancerous tumour

Action of a beta blocker drug, artwork
Action of a beta blocker drug on nerve synapses, artwork. Beta blockers are used to treat cardiac arrhythmia (abnormal heartbeats) and hypertension (high blood pressure)

Action of serotonin reuptake inhibitors
Action of selective serotonin reuptake inhibitors (SSRIs) at a chemical synapse, computer artwork. Chemical synapses are the junctions between any two nerves (at right, blue) of the nervous system

Antibiotic mechanism of action, artwork
Antibiotic mechanism of action. Computer artwork showing the sites where two different families of antibiotics exert their effects on messenger RNA (mRNA)

Immune system, artwork
Immune system. Computer artwork showing how T-cells (right), antibodies (Y-shaped) and antigen-presenting cells (APC, left) interact during an immune response

Cholesterol producing enzyme and statin. Computer model showing the molecular structure of HMG-CoA reductase (HMGCR) in complex with Atorvastatin

RNA interference viral suppressor and RNA. Computer model showing the molecular structure of the p19 protein (pink, top) from a Tombusvirus, suppressing a double-stranded

Renin and inhibitor complex. Computer model showing the secondary structure of the enzyme renin complexed with inhibitor 7

Vancomycin antibiotic action. Computer model showing the secondary structure of the enzyme glycosyltransferase (spirals and ribbons)

Vildagliptin diabetes drug molecule, computer model. Vildagliptin, which is marketed as Galvus by Novartis, belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs

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"Inhibiting: Unlocking the Secrets of Molecular Control" In the intricate world of molecular biology, inhibiting certain processes can hold the key to understanding and manipulating various biological functions. From anaesthetics blocking ion channels to potent inhibitors combating deadly viruses, scientists delve into these captivating mechanisms. Captured in stunning artwork, we witness an anaesthetic molecule skillfully inhibiting an ion channel (C015 / 6718). This interaction disrupts nerve signals, leading to temporary loss of sensation during medical procedures. The enigmatic ricin A-chain (C017 / 3653) takes center stage as it showcases its lethal potential. Its ability to inhibit protein synthesis within cells makes it a formidable toxin. The intricately designed ricin molecules (C017 / 3652-3651) further emphasize their dangerous nature. However, science also harnesses inhibition for positive purposes. HIV-1 protease and inhibitor complex (F006 / 9773) represents a breakthrough in antiretroviral therapy by targeting viral enzymes crucial for replication. Similarly, the kinase inhibitor complex (F006 / 9760) offers hope in cancer treatment by hindering abnormal cell growth pathways. As we explore further, we encounter a fascinating battle between a flu virus surface protein and a drug molecule (F006 / 9745). Inhibition prevents viral entry into host cells and potentially curbs influenza outbreaks. The HIV reverse transcription enzyme (F006 / 9684), responsible for converting viral RNA into DNA within human cells, faces resistance from inhibitors aiming to impede its activity. These inhibitors play a vital role in managing HIV infections worldwide. Lastly, we uncover the intriguing concept of RNA interference through the interplay between a viral suppressor and RNA molecules (F006/9488). By inhibiting gene expression at specific points along the genetic pathway, researchers unlock new possibilities for treating genetic disorders or combating harmful viruses.