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Anaesthetic inhibiting an ion channel C015 / 6718

Anaesthetic inhibiting an ion channel C015  /  6718


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Anaesthetic inhibiting an ion channel C015 / 6718

Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres, lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey and blue). Propofol is used for inducing and maintaining general anaesthesia. pLGICs are targeted by general anaesthetics such as propofol which bind to the extracellular interface between the channels five monomers (subunits) and inhibit its action

Science Photo Library features Science and Medical images including photos and illustrations

Media ID 9214435

© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Anaesthesiology Anaesthetic Analgesia Anesthesia Anesthetic Binding Bound Cell Biology Channel Complex Complexed Cytological Cytology Drug Electron Density General Anaesthesia Inhibiting Inhibition Interacting Interaction Ion Channel Lgic Lgics Ligand Gated Ion Channel Molecules Nmda Receptor Antagonist Pentameric Ligand Gated Ion Channel Pharmacological Pharmacology Plgic Plgics Proteins Proteomics Quaternary Structure Receptor Receptors Ribbon Structure Secondary Structure System Biochemical Biochemistry Cutouts Molecular Model Molecular Structure Protein


EDITORS COMMENTS
This print showcases the intricate structure of propofol anaesthetic drug molecules bound to a pentameric ligand-gated ion channel (pLGIC). The computer model reveals the detailed interaction between these two components, shedding light on how propofol inhibits the action of this ion channel. Propofol is a widely used anaesthetic for inducing and maintaining general anesthesia, making it an essential tool in medical practice. By binding to the extracellular interface between the five monomers of the pLGIC, propofol effectively hinders its normal functioning. The white background emphasizes the complexity of this biochemical interaction, highlighting both the beauty and significance of this molecular system. The illustration represents a cut-out view that allows us to delve into the realm of cell biology and cytology. Through this image, we gain insight into how proteins and molecules interact within our bodies at a microscopic level. It serves as a reminder of how advancements in pharmacology and biochemistry contribute to our understanding and development of effective medical treatments. Ramon Andrade's artwork not only captures scientific intricacies but also presents them in an aesthetically pleasing manner. This print is a testament to his expertise in creating visually stunning representations that bridge art and science seamlessly.

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