Inhibition Collection

Anaesthetic inhibiting an ion channel C015 / 6718
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Januvia diabetes drug molecule
Januvia diabetes drug, molecular model. Januvia (sitagliptin) is a hypoglycaemic drug, one that reduces blood sugar levels

The Jester; Le Bouffon, 1868 (oil on canvas)
823620 The Jester; Le Bouffon, 1868 (oil on canvas) by Blanchard, Edouard-Theophile (1844-79); 146.5x241 cm; Private Collection; (add.info.: The Jester; Le Bouffon)

Ricin A-chain, artwork C017 / 3653
Ricin A-chain. Computer artwork showing the enzymatically active A-chain from a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (seen here) and B (not shown)

Ricin molecule, artwork C017 / 3652
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3651
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3650
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Loss of inhibition, conceptual artwork F007 / 8262
Loss of inhibition, conceptual computer artwork

Ricin A-chain, artwork C017 / 3654
Ricin A-chain. Computer artwork showing the enzymatically active A-chain from a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (seen here) and B (not shown)

Ricin molecule, artwork C017 / 3649
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Cobicistat HIV drug F007 / 0134
Cobicistat HIV drug, molecular model. Cobicistat is a booster drug that slows down the breakdown of other HIV medicines and therefore is used in the combination drug treatment of HIV

Cobicistat HIV drug F007 / 0133
Cobicistat HIV drug, molecular model. Cobicistat is a booster drug that slows down the breakdown of other HIV medicines and therefore is used in the combination drug treatment of HIV

Cobicistat HIV drug F007 / 0132
Cobicistat HIV drug, molecular model. Cobicistat is a booster drug that slows down the breakdown of other HIV medicines and therefore is used in the combination drug treatment of HIV

HIV-1 protease and inhibitor F006 / 9773
HIV-1 protease and inhibitor. Molecular model of the enzyme HIV-1 protease (pink and blue ribbons) bound to an inhibitor molecule (centre)

LAC repressor molecule F006 / 9520
LAC repressor. Molecular model of a LAC (lactose) repressor molecule. The LAC repressor inhibits the expression of genes that code for an enzyme which metabolizes lactose in bacteria

RNA interference viral suppressor and RNA F006 / 9488
RNA interference viral suppressor and RNA. Molecular model of the p19 protein (yellow) from a Tombusvirus, suppressing a double-stranded, small interfering RNA (siRNA) molecule (red and blue)

LAC repressor bound to DNA F006 / 9309
LAC repressor bound to DNA. Molecular model of a LAC (lactose) repressor molecule (pink and turquoise) interacting with bacterial DNA (deoxyribonucleic acid, red and blue)

Acetylcholine receptor-conotoxin complex. Molecular model showing alpha-conotoxin bound to a nicotinic acetlycholine receptor

Grapefruit and drugs C016 / 8811
Many of the drugs that are usually prescribed and essential for the treatment of common medical conditions interact adversely with grapefruit, grapefruit juice and some other citrus fruits

Ricin molecule, artwork C017 / 3656
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3655
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3648
Ricin molecule Computer artwork showing the structure of a molecule of the toxic protein ricin (blue and yellow) with an active ribosome in the background

Bone morphogenetic protein complex, molecular model. Bone Morphogenetic Protein-7 (BMP-7, blue) in complex with the secreted antagonist Noggin (pink)

Anaesthetic inhibiting an ion channel C015 / 6723
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres) bound to a pentameric ligand-gated ion channel (pLGIC, blue ribbons)

Coagulation factor complex molecule C014 / 0626
Coagulation factor complex molecule. Molecular model showing a blood clotting factor VIIa-tissue factor complex molecule (blue and white ribbons) with a tissue factor pathway inhibitor (TFPI)

Anaesthetic inhibiting an ion channel C015 / 6722
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres) bound to a pentameric ligand-gated ion channel (pLGIC, blue ribbons)

Anaesthetic inhibiting an ion channel C015 / 6720
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey)

Anaesthetic inhibiting an ion channel C015 / 6721
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Anaesthetic inhibiting an ion channel C015 / 6719
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres)

Coagulation factor complex molecule C014 / 0585
Coagulation factor complex molecule. Molecular model showing a blood clotting factor VIIa-tissue factor complex molecule (blue and white) with a tissue factor pathway inhibitor (TFPI)

Coagulation factor complex molecule C014 / 0584
Coagulation factor complex molecule. Molecular model showing a blood clotting factor VIIa-tissue factor complex molecule (blue and white ribbons) with a tissue factor pathway inhibitor (TFPI)

Tryptophan repressor bound to DNA C015 / 6243
Tryptophan repressor bound to DNA. Molecular model of the tryptophan (trp) repressor (grey and green, and orange and yellow, across bottom) bound to DNA (deoxyribonucleic) molecules (blue and orange)

Tryptophan repressor bound to DNA C015 / 6242
Tryptophan repressor bound to DNA. Molecular model of the tryptophan (trp) repressor (purple and green, and pink and beige, across bottom) bound to DNA (deoxyribonucleic) molecules (blue and orange)

RNA interference viral suppressor molecule. Computer model showing the molecular structure of the p21 protein from a beet yellow virus

Preventing cancer spreading, artwork C013 / 8816
Preventing cancer spreading, conceptual artwork. Cancer cells inside a geodesic cage, representing the prevention of metastasis - spreading to other tissues of the body

Angiogenesis inhibitors, conceptual image C013 / 7789
Angiogenesis inhibitors, conceptual image. Computer artwork showing a brick wall preventing new blood vessels from reaching a cancerous tumour

Action of a beta blocker drug, artwork
Action of a beta blocker drug on nerve synapses, artwork. Beta blockers are used to treat cardiac arrhythmia (abnormal heartbeats) and hypertension (high blood pressure)

Antibiotic mechanism of action, artwork
Antibiotic mechanism of action. Computer artwork showing the sites where two different families of antibiotics exert their effects on messenger RNA (mRNA)

Immune system, artwork
Immune system. Computer artwork showing how T-cells (right), antibodies (Y-shaped) and antigen-presenting cells (APC, left) interact during an immune response

Cholesterol producing enzyme and statin. Computer model showing the molecular structure of HMG-CoA reductase (HMGCR) in complex with Atorvastatin

RNA interference viral suppressor and RNA. Computer model showing the molecular structure of the p19 protein (pink, top) from a Tombusvirus, suppressing a double-stranded

Hantavirus inhibitor molecule. Molecular model of a pentapeptide protein that blocks the entry of hantavirus particles to human cells

Adenosine crystals, light micrograph
Adenosine crystals, polarised light micrograph. Adenosine is a nucleoside molecule composed of the base adenine bonded to the sugar ribose

GABA crystals, light micrograph
GABA crystals. Polarised light micrograph of gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter (nerve signalling chemical) that regulates the excitability of all nerve cells

Proteinase inhibitor molecule
Proteinase inhibitor. Molecular model showing the secondary structure of alpha-1 proteinase inhibitor, also known as alpha 1-antitrypsin

Somatostatin hormone molecule. Computer model showing the structure of the hormone somatostatin, also known as growth hormone-inhibiting hormone (GHIH)

Renin and inhibitor complex. Computer model showing the secondary structure of the enzyme renin complexed with inhibitor 7

Tacrine Alzheimers drug molecule
Tacrine. Molecular model of the Alzheimers drug tacrine, marketed under the name Cognex. Atoms are represented as spheres and are colour-coded: carbon (blue)

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"Inhibition: Unveiling the Complexities of Control" Inhibition, a multifaceted concept, encompasses various realms of human existence. From the intricate workings of our bodies to artistic expressions and societal dynamics, inhibition shapes our experiences in profound ways. At the molecular level, we witness inhibition's power through anaesthetics that target ion channels like C015/6718. These remarkable substances selectively block these channels, temporarily numbing pain and allowing medical procedures to be performed with ease. Similarly, Januvia diabetes drug molecule stands as a testament to inhibition's potential for improving lives. By inhibiting specific enzymes involved in glucose regulation, this medication helps manage blood sugar levels for individuals battling diabetes. Beyond science and medicine lies the realm of artistry. "The Jester; Le Bouffon" by an unknown artist from 1868 captures the essence within its strokes on canvas. The jester's playful facade conceals layers of restraint and self-censorship necessary to navigate social expectations during that era. Moving back into scientific territory, we encounter Ricin A-chain (artwork C017/3653) alongside several depictions (C017/3652-3651). These artworks unveil how ricin molecules inhibit protein synthesis within cells—a chilling reminder of nature's potent mechanisms capable of causing harm if not understood or controlled. However, not all forms are detrimental. In fact, some conceptualize it as a loss—depicted eloquently in artwork F007/8262 titled "Loss of Inhibition. " This thought-provoking piece invites contemplation about breaking free from societal constraints while acknowledging potential consequences when boundaries dissolve entirely. Returning once more to ricin-related artworks (C017/3654-3649), we delve deeper into understanding its structure and function—an essential step towards developing countermeasures against this deadly toxin.