Coagulation factor complex molecule C014 / 0585
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Coagulation factor complex molecule C014 / 0585
Coagulation factor complex molecule. Molecular model showing a blood clotting factor VIIa-tissue factor complex molecule (blue and white) with a tissue factor pathway inhibitor (TFPI, spheres top right) molecule bound. Tissue factor, also known as factor III, is found on the outside of blood vessels. When the vessel is injured it comes into contact with factor VII (FVII) circulating in the blood stream. They bind together, activating FVII as apart of the coagulation cascade, the physiological process that leads to blood clotting in the case of injury. Molecules further down the cascade activate TFPI, suppressing the cascade
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9212231
© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
Coagulation Complex Compound Enzyme Inhibition Negative Feedback Secondary Structure Serine Protease Biochemical Biochemistry Molecular Molecular Model Protein
EDITORS COMMENTS
This print showcases the intricate molecular structure of a coagulation factor complex molecule, specifically Coagulation factor complex molecule C014 / 0585. The blue and white model represents the blood clotting factor VIIa-tissue factor complex molecule, while the spherical structures in the top right corner depict a tissue factor pathway inhibitor (TFPI) molecule bound to it. Tissue factor, also known as factor III, is naturally present on the outer surface of blood vessels. When an injury occurs, it comes into contact with circulating factor VII (FVII) in the bloodstream. This interaction leads to their binding together and activating FVII as part of the coagulation cascade - a vital physiological process that triggers blood clotting to prevent excessive bleeding. Further down this cascade, other molecules activate TFPI, which acts as a suppressor for this intricate process. TFPI plays an essential role in negative feedback regulation by inhibiting certain factors involved in blood clot formation. The artwork beautifully highlights these biochemical interactions within our bodies that are crucial for maintaining hemostasis during injuries or trauma. It serves as a visual reminder of how intricately interconnected our biological systems are at a molecular level. Ramon Andrade's stunning illustration not only captures the complexity and beauty of these molecules but also provides valuable insights into biochemistry and human biology.
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