Anaesthetic inhibiting an ion channel C015 / 6721
Wall Art and Photo Gifts from Science Photo Library
Anaesthetic inhibiting an ion channel C015 / 6721
Anaesthetic inhibiting an ion channel. Computer model showing the structure of propofol anaesthetic drug molecules (spheres, lower left and right) bound to a pentameric ligand-gated ion channel (pLGIC, grey). Propofol is used for inducing and maintaining general anaesthesia. pLGICs are targeted by general anaesthetics such as propofol which bind to the extracellular interface between the channels five monomers (subunits) and inhibit its action
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9214509
© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
Anaesthesiology Anaesthetic Analgesia Anesthesia Anesthetic Binding Bound Cell Biology Channel Complex Complexed Cytological Cytology Drug Electron Density General Anaesthesia Inhibiting Inhibition Interacting Interaction Ion Channel Lgic Lgics Ligand Gated Ion Channel Molecules Nmda Receptor Antagonist Pentameric Ligand Gated Ion Channel Pharmacological Pharmacology Plgic Plgics Proteins Proteomics Quaternary Structure Receptor Receptors System Biochemical Biochemistry Cutouts Molecular Model Molecular Structure Protein
EDITORS COMMENTS
This print showcases the intricate structure of propofol anaesthetic drug molecules bound to a pentameric ligand-gated ion channel (pLGIC). The computer-generated model reveals the complex interaction between these molecules and the ion channel, shedding light on how propofol induces and maintains general anesthesia. The image features propofol drug molecules represented as spheres, elegantly positioned in the lower left and right corners. These molecules are shown binding to the pLGIC, depicted in grey, which forms a channel-like structure. By targeting this specific type of ion channel, general anesthetics like propofol inhibit its action, leading to profound sedation during medical procedures. The white background enhances the clarity of this scientific illustration while emphasizing the importance of understanding this biochemical interaction for advancements in medicine. This artwork combines elements from chemistry, cell biology, pharmacology, and molecular modeling to provide a comprehensive visual representation. Ramon Andrade's expertise shines through his meticulous attention to detail in creating this stunning piece. His work not only highlights the beauty within science but also serves as a valuable tool for researchers studying anesthesiology and analgesia. Overall, this print captures both the complexity and elegance inherent in exploring molecular structures involved in anesthesia. It is a testament to scientific progress and our ongoing quest for safer and more effective methods of inducing general anesthesia.
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