Tertiary Structure Collection

Manganese superoxide dismutase enzyme F006 / 9423
Manganese superoxide dismutase enzyme, molecular model. This enzyme scavenges and decomposes the potentially toxic first reduction product, superoxide, of aerobic respiration

RNA binding protein and mRNA complex

Calcium ATPase ion pump, molecular model. This enzyme is found in muscle cell membranes, where it pumps calcium in and out of muscle cells and controls muscle contractions

Argonaute protein and microRNA F006 / 9752
Argonaute protein. Molecular model of human argonaute-2 protein complexed with microRNA (micro ribonucleic acid). This protein is part of the RNA-induced silencing complex (RISC)

Immunoglobulin G antibody and egg white F006 / 9682
Immunoglobulin G and egg white. Molecular model of an immunoglobulin G (IgG) antibody bound to a molecule of egg white. This is the most abundant immunoglobulin and is found in all body fluids

Foot-and-mouth disease virus F006 / 9556
Foot-and-mouth disease virus. Molecular model of the foot-and-mouth disease (FMD) virus (Aphtae epizooticae) protein coat (capsid)

Argonaute protein molecule F006 / 9526
Argonaute protein, molecular model. This protein forms the RNA-induced silencing complex (RISC) along with a small interfering RNA (ribonucleic acid) molecule

Rubisco enzyme molecule F006 / 9779
Rubisco. Molecular model of the enzyme rubisco (ribulose bisphosphate carboxylase oxygenase) complexed with ribulose-1, 5-biphosphate

Rhinovirus capsid, molecular model F006 / 9737
Rhinovirus capsid, molecular model. This is human rhinovirus. The rhinovirus infects the upper respiratory tract and is the cause of the common cold. It is spread by coughs and sneezes

Isocitrate dehydrogenase kinase F006 / 9698
Isocitrate dehydrogenase kinase. Molecular model of isocitrate dehydrogenase kinase phosphatase (AceK) complexed with its substrate isocitrate dehydrogenase (ICDH)

Cytochrome P450 complex F006 / 9669
Cytochrome P450 complex. Molecular model of a complex composed of cytochrome P450, carbon monoxide and camphor

Integrin and fibrinogen complex molecule F006 / 9649
Integrin and fibrinogen complex. Molecular model of integrin alpha-II beta-3 complexed with fibrinogen. Integrin alpha-II beta-3 is a transmembrane protein found on platelets

E coli virulence factor F006 / 9639
E. coli virulence factor. Molecular model of the beta-domain of the EspP autotransporter protein from the bacterium Escherichia coli

Trypsin molecule F006 / 9634
Trypsin molecule. Molecular model of the digestive protease enzyme trypsin. Trypsin is released by the pancreas to break down proteins into smaller chains of amino acids

Thrombin protein, molecular model F006 / 9603
Thrombin protein, molecular model. Thrombin is an enzyme involved in the blood coagulation (clotting) process

Succinyl-CoA synthetase enzyme F006 / 9592
Succinyl-CoA synthetase bound to GTP, molecular model. Also known as succinyl coenzyme A synthetase (SCS), this enzyme catalyses the reversible reaction between succinyl-CoA and succinic acid

RNA-induced silencing complex F006 / 9586
RNA-induced silencing complex (RISC), molecular model. This complex consists of a bacterial argonaute protein (top) bound to a small interfering RNA (siRNA) molecule (red and blue)

Chymotrypsin inhibitor 2 molecule F006 / 9578
Chymotrypsin inhibitor 2, molecular model. This enzyme is a serine protease inhibitor (serpin) found in barley (Hordeum vulgare) seeds

Adenovirus penton base protein F006 / 9542
Adenovirus penton base protein, molecular model. This protein molecule is a subunit called a penton, forming the vertices of the capsid of this adenovirus

Rhinovirus capsid, molecular model F006 / 9490
Rhinovirus capsid, molecular model. This is human rhinovirus. The rhinovirus infects the upper respiratory tract and is the cause of the common cold. It is spread by coughs and sneezes

Foot-and-mouth disease virus F006 / 9471
Foot-and-mouth disease virus

Rhinovirus 16 capsid, molecular model F006 / 9431
Rhinovirus 16 capsid, molecular model. This is human rhinovirus 16. The rhinovirus infects the upper respiratory tract and is the cause of the common cold. It is spread by coughs and sneezes

Rhinovirus 14 capsid, molecular model F006 / 9430
Rhinovirus 14 capsid, molecular model. This is human rhinovirus 14. The rhinovirus infects the upper respiratory tract and is the cause of the common cold. It is spread by coughs and sneezes

Citrate acid cycle enzyme F006 / 9305
Citrate acid cycle enzyme. Molecular model of the enzyme dihydrolipoamide succinyltransferase

Citrate synthase molecule F006 / 9277
Citrate synthase, molecular model. This enzyme is involved in the first step of the citric acid (or Krebs) cycle, the process by which mitochondria convert glucose to energy

Acetylcholinesterase molecule F006 / 9226
Acetylcholinesterase, molecular model. This enzyme hydrolyses the neurotransmitter acetylcholine, stopping signal transmission

RNA-Induced Silencing Complex (RISC)

Feline distemper virus particle. Molecular model showing the structure of the capsid (outer protein coat) of a feline panleukopenia virus particle. This parovirus causes distemper in cats

Thyroid-stimulating hormone molecule. Computer model showing the structure of a molecule of thyroid stimulating hormone (TSH)

Tumour suppressor protein and DNA C017 / 3647
Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange)

Ricin A-chain, artwork C017 / 3653
Ricin A-chain. Computer artwork showing the enzymatically active A-chain from a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (seen here) and B (not shown)

Ricin molecule, artwork C017 / 3652
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Sirtuin enzyme and p53, artwork C017 / 3659
Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (pink) bound to a p53 peptide (orange)

Tumour suppressor protein and DNA C017 / 3644
Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange)

Ricin molecule, artwork C017 / 3651
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Ricin molecule, artwork C017 / 3650
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Sirtuin enzyme and p53, artwork C017 / 3658
Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (pink) bound to a p53 peptide (orange)

SIRT3 molecule, artwork C017 / 3657
SIRT3 molecule. Computer artwork showing the structure of a molecule of NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3)

Tumour suppressor protein and DNA C017 / 3646
Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange)

Haemagglutinin viral surface protein F007 / 9932
Haemagglutinin viral surface protein. Molecular model of haemagglutinin, a surface protein from the influenza virus, complexed with a neutralising antibody

Haemagglutinin viral surface protein F007 / 9931
Haemagglutinin viral surface protein. Molecular model of haemagglutinin, a surface protein from the influenza virus, complexed with a neutralising antibody

Human 80S ribosome F007 / 9902
Ribosomal subunit. Computer model showing the structure of the RNA (ribonucleic acid) molecules in an 80S (large) ribosomal sub-unit. Ribosomes are composed of protein and RNA

Human 80S ribosome F007 / 9898
Ribosomal subunit. Computer model showing the structure of the RNA (ribonucleic acid) molecules in an 80S (large) ribosomal sub-unit. Ribosomes are composed of protein and RNA

Tumour suppressor protein and DNA C017 / 3645
Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange)

Ricin A-chain, artwork C017 / 3654
Ricin A-chain. Computer artwork showing the enzymatically active A-chain from a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (seen here) and B (not shown)

Sirtuin enzyme and p53, artwork C017 / 3660
Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (blue) bound to a p53 peptide (pink)

Ricin molecule, artwork C017 / 3649
Ricin molecule. Computer artwork showing the structure of a molecule of the toxic protein ricin. Ricin comprises two entwined amino acid chains; A (yellow) and B (blue)

Rubisco enzyme molecule F006 / 9776
Rubisco. Molecular model of the enzyme rubisco (ribulose bisphosphate carboxylase oxygenase) complexed with 2-carboxyarabinitol biphosphate

NADP-dependent isocitrate dehydrogenase F006 / 9778
NADP-dependent isocitrate dehydrogenase, molecular model. This enzyme catalyses the third step in the citric acid (or Krebs) cycle, the process by which mitochondria convert glucose to energy

Catalase, molecular model F006 / 9774
Catalase. Molecular model of catalase from a cow liver. This enzyme to water and oxygen. Hydrogen peroxide is a highly toxic byproduct of a number of normal cellular processes

Glycogen phosphorylase molecule F006 / 9775
Glycogen phosphorylase. Molecular model of glycogen phosphorylase bound to AMP (adenosine monophosphate)

Triose phosphate isomerase molecule F006 / 9777
Triose phosphate isomerase (TPI), molecular model. TPI is essential for glycolysis and catalyses the reversible interconversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate

Bacterial alpha-hemolysin toxin F006 / 9771
Bacterial alpha-hemolysin toxin, molecular model. This toxin is secreted by the bacterium Staphylococcus aureus

Metabolic enzyme molecule F006 / 9770
Metabolic enzyme. Molecular model of the enzyme aconitase with isocitrate bound. Aconitase is involved in the citric acid (or Krebs) cycle

Dihydrofolate reductase molecule F006 / 9772
Dihydrofolate reductase, molecular model. This enzyme converts the vitamin folic acid into a coenzyme

HIV-1 protease and inhibitor F006 / 9773
HIV-1 protease and inhibitor. Molecular model of the enzyme HIV-1 protease (pink and blue ribbons) bound to an inhibitor molecule (centre)

Ribonuclease A molecule F006 / 9768
Ribonuclease A (RNAse A), molecular model

Pepsin stomach enzyme F006 / 9767
Pepsin stomach enzyme, molecular model. Pepsin is a protease enzyme that is secreted as part of gastric juice into the stomach in an inactive form known as pepsinogen

Flock house virus capsid F006 / 9755
Flock house virus capsid, molecular model. The flock house virus is a member of the Nodaviridae family. It kills the New Zealand grass grub insect

Xylose isomerase complex F006 / 9765
Xylose isomerase complex. Molecular model of the enzyme D-xylose isomerase bound to the sugar alcohol sorbitol. D-xylose isomerase is involved in fructose and mannose metabolism

H-Ras p21 oncogene protein F006 / 9766
H-Ras p21 oncogene protein, molecular model. The Ras proteins are involved in transmitting signals within cells

Phosphofructokinase bacterial enzyme F006 / 9762
Phosphofructokinase enzyme, molecular model. This enzyme, from the bacterium Bacillus stearothermophilus, is involved in regulating the process of releasing energy from glucose

tRNA molecule F006 / 9764
Transfer RNA (tRNA), molecular model. tRNA (transfer ribonucleic acid) translates messenger RNA (mRNA) into a protein product

H-Ras p21 oncogene protein F006 / 9763
H-Ras p21 oncogene protein, molecular model. The Ras proteins are involved in transmitting signals within cells

Kinase inhibitor complex F006 / 9760
Kinase inhibitor complex. Molecular model of a leucettine kinase inhibitor bound to a serine threonine kinase protein

Marburg viral protein 35 and RNA F006 / 9759
Marburg viral protein 35 and RNA. Molecular model of the Marburg viral protein 35 (VP35) bound to a molecule of double stranded RNA (ribonucleic acid)

Insulin molecule F006 / 9761
Insulin molecule. Molecular model of the hormone insulin from a pig. Insulin consists of two peptide chains, A and B, which are linked by disulphide bridges

Eye lens protein molecule F006 / 9758
Eye lens protein. Molecular model of gammaB-crystallin, a protein found in the lens of the eye. The regular arrangement of the protein in the lens is thought to be responsible for its transparency

Methionine aminopeptidase molecule F006 / 9756
Methionine aminopeptidase, molecular model. This enzyme removes the amino acid methionine from proteins

Hepatitis C glycoprotein and antibody F006 / 9757
Hepatitis C glycoprotein and antibody. Molecular model of the E2 envelope glycoprotein from the hepatitis C virus bound to a neutralising antibody

Malignant brain-tumor-like protein F006 / 9754
Malignant brain-tumour-like protein. Molecular model of the human lethal(3) malignant brain-tumour-like protein (Malignant brain-tumour-like protein (L3MBTL3)

Guanine-responsive riboswitch F006 / 9753
Guanine-responsive riboswitch, molecular model. This protein regulates gene expression by binding to the nucleotide guanine to switch off transcription

UV-damaged DNA-binding protein and DNA F006 / 9750
UV-damaged DNA-binding protein and DNA. Molecular model of UV-damaged DNA-binding protein (UV-DDB) complexed with DNA (deoxyribonucleic acid, red and blue)

Plexin signal transduction molecule F006 / 9751
Plexin signal transduction molecule. Molecular model of plexin-A4 a signal transduction protein that is involved in neural maintenance and regeneration

Multidrug efflux pump molecule F006 / 9748
Multidrug efflux pump. Molecular model of the multidrug efflux pump AcrB from the bacterium Escherichia coli transporting two doxorubicin molecules

RNA triplet repeat expansion F006 / 9749
RNA triplet repeat expansion. Molecular model of a CUG triplet repeat expansion in a molecule of double stranded RNA (ribonucleic acid)

Flu virus surface protein and drug F006 / 9745
Flu virus surface protein and drug. Molecular model of the neuraminidase glycoprotein enzyme from on the surface of the influenza A (flu) virus bound to the drug zanamivir

Human lysine-specific demethylase F006 / 9747
Human lysine-specific demethylase, molecular model. This enzyme removes methyl groups from lysine residues in histones (proteins that package DNA)

Beta-lactamase molecule F006 / 9746
Beta-lactamase enzyme, molecular model. This bacterial protein provides resistance to beta-lactam antibiotics, which include penicillin

Human muscle aldolase, molecular model F006 / 9742
Human muscle aldolase. Molecular model of the enzyme human muscle aldolase complexed with its substrate fructose 1, 6-bisphosphate

ATP-binding cassette transporter F006 / 9743
ATP-binding cassette transporter. Molecular model of the human mitochondrial ATP-binding cassette transporter ABCB10. This protein is found on the inner membrane of mitochondria

Transcription factor bound to DNA F006 / 9744
Transcription factor bound to DNA. Molecular model of the human ETS translocation variant 1 (etv1) bound to a molecule of DNA (deoxyribonucleic acid)

Beta-lactamase-like protein 2 molecule F006 / 9741
Beta-lactamase-like protein 2, molecular model

Stress-responsive activator protein F006 / 9740
Stress-responsive activator protein. Molecular model of the stress-responsive activator of p300 (strap) protein

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EDITORS COMMENTS

Tertiary structure is a fascinating aspect of molecular biology that plays a crucial role in the functionality and stability of various biological molecules. One such example is the Manganese superoxide dismutase enzyme F006 / 9423, which possesses an intricate tertiary structure that allows it to efficiently scavenge harmful reactive oxygen species. Another intriguing molecule with a well-defined the Argonaute protein F006 / 9526. This protein acts as a key component of RNA-induced silencing complex F006 / 9586, enabling it to bind microRNAs and regulate gene expression through post-transcriptional mechanisms. The Immunoglobulin G antibody and egg white F006 / 9682 exhibit an interesting interaction where the tertiary structure of the antibody enables it to recognize specific antigens present in egg white, triggering an immune response. Cytochrome P450 complex F006 / 9669 showcases how multiple proteins come together to form a functional unit responsible for metabolizing drugs and toxins in our bodies. The precise arrangement of these proteins within their tertiary structures ensures efficient catalytic activity. Succinyl-CoA synthetase enzyme F006 / 9592 participates in the citric acid cycle (also known as Krebs cycle) by converting succinyl-CoA into ATP. Its unique tertiary structure facilitates substrate binding and enzymatic reactions essential for energy production. Viruses also possess captivating tertiary structures; one example being Foot-and-mouth disease virus F006 / 9556. Understanding its intricate capsid architecture aids researchers in developing effective vaccines against this highly contagious viral infection. Adenovirus penton base protein F006 / 9542 exhibits an elaborate tertiary structure critical for viral entry into host cells during infection. Studying this protein's conformation provides insights into potential therapeutic targets against adenoviral infections. Rhinovirus 16 capsid, molecular model F006/9431 represents another virus with a well-characterized tertiary structure.