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Sirtuin enzyme and p53, artwork C017 / 3660
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Sirtuin enzyme and p53, artwork C017 / 3660
Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (blue) bound to a p53 peptide (pink). Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases that are required for diverse biological processes, including transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilisation, and lifespan regulation. NAD is shown as a stick model (centre). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 9262451
© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY
Binding Bound Cell Cycle Complex Complexed Metabolic Metabolism Peptide Preventative Prevention Proteins Proteomics Regulation Regulator Secondary Structure Tertiary Structure Tumor Suppressor Tumour Suppressor Protein Biochemical Biochemistry Molecular Model Protein
EDITORS COMMENTS
This artwork, titled "Sirtuin Enzyme and p53" showcases the intricate relationship between a sirtuin enzyme (Sir2) and a p53 peptide. The computer-generated image beautifully depicts the binding of these two crucial molecules in vibrant shades of blue and pink. The Sir2 enzymes belong to a unique class of NAD (+)-dependent deacetylases that play essential roles in various biological processes. They are involved in transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilization, and even lifespan regulation. In this artwork, the Sir2 enzyme is depicted as a striking blue structure bound to the pink p53 peptide. p53 is an indispensable protein found in multicellular organisms that regulates the cell cycle and prevents damaged DNA from proliferating. Its significance lies in its ability to maintain cellular integrity by ensuring proper replication while eliminating cells with faulty genetic material. The central stick model represents NAD, which serves as an important coenzyme for many metabolic reactions within cells. This illustration highlights the biochemical complexity behind this binding event, emphasizing how these molecules work together as regulators within our bodies. Ramon Andrade's 3DCIENCIA/SCIENCE PHOTO LIBRARY has masterfully captured this intricate molecular dance through their stunning artistic representation. This artwork not only celebrates scientific discovery but also reminds us of the beauty hidden within our own biology.
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