Tumour suppressor protein and DNA C017 / 3647

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Tumour suppressor protein and DNA C017 / 3647

Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA. It is produced in response to radiation and chemicals that damage the structure of DNA, when it binds to specific sequences in the DNA and halts the cell cycle. If there is only minor damage, p53 activates genes involved in DNA repair, but if the damage cannot be repaired it initiates cell death (apoptosis). p53 plays a very important role in preventing the replication of cancerous cells, so

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Media ID 9342203

© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Binding Bound Cell Cycle Complex Complexed Gene Genes Genetic Molecules Preventative Prevention Proteins Proteomics Quaternary Structure Secondary Structure Strand Tertiary Structure Tetramer Tumor Suppressor Tumour Suppressor Protein Biochemical Biochemistry Deoxyribonucleic Acid Genetics Molecular Model Protein

EDITORS COMMENTS
This print showcases a computer-generated artwork depicting the intricate relationship between a tumour suppressor protein and DNA. The image beautifully illustrates a molecule of the p53 tumour suppressor protein, represented in shades of blue and pink, bound to a molecule of DNA, portrayed in vibrant yellow and orange hues. The p53 protein is an essential component in multicellular organisms as it plays a crucial role in regulating the cell cycle and preventing the proliferation of cells with damaged DNA. When exposed to radiation or chemicals that harm DNA structure, p53 binds to specific sequences within the DNA strand, effectively halting the cell cycle. In cases where minor damage occurs, p53 activates genes responsible for repairing DNA. However, if irreparable damage is detected, this remarkable protein initiates programmed cell death known as apoptosis. By actively preventing cancerous cells from replicating, p53 assumes an incredibly significant role in safeguarding our bodies against tumor development. This complex interaction between proteins and genes highlights its importance as a preventative measure against malignant growths. Ramon Andrade's stunning artwork not only captures the structural beauty of these biochemical entities but also serves as a reminder of their vital functions within our genetic makeup. This image provides us with valuable insights into proteomics and genetics while showcasing the quaternary structure formation through tetramerization—a truly mesmerizing display at both molecular and artistic levels.

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