Tumour suppressor protein and DNA C017 / 3646

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Tumour suppressor protein and DNA C017 / 3646

Tumour suppressor protein and DNA. Computer artwork showing a molecule of the tumour suppressor protein p53 (blue and pink) bound to a molecule of DNA (deoxyribonucleic acid, yellow and orange). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA. It is produced in response to radiation and chemicals that damage the structure of DNA, when it binds to specific sequences in the DNA and halts the cell cycle. If there is only minor damage, p53 activates genes involved in DNA repair, but if the damage cannot be repaired it initiates cell death (apoptosis). p53 plays a very important role in preventing the replication of cancerous cells, so

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Media ID 9339887

© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Binding Bound Complex Complexed Gene Genes Genetic Molecules Preventative Prevention Proteins Proteomics Quaternary Structure Secondary Structure Strand Tertiary Structure Tumor Suppressor Tumour Suppressor Protein Biochemical Biochemistry Deoxyribonucleic Acid Genetics Molecular Model Protein

EDITORS COMMENTS
This print showcases a computer-generated artwork depicting the intricate interaction between a tumour suppressor protein and DNA. The image displays the tumour suppressor protein p53, represented in shades of blue and pink, bound to a molecule of DNA depicted in vibrant yellow and orange hues. The significance of p53 cannot be overstated in the realm of multicellular organisms as it plays a vital role in regulating the cell cycle, which governs cellular replication. Additionally, this remarkable protein prevents the proliferation of cells with damaged DNA by responding to radiation or chemical-induced damage. By binding to specific sequences within the DNA strand, p53 effectively halts the cell cycle. In cases where minor damage is detected, p53 activates genes responsible for repairing damaged DNA strands. However, if repair is deemed impossible, p53 initiates programmed cell death known as apoptosis. This crucial mechanism ensures that cancerous cells are not allowed to replicate uncontrollably. The complex nature of this biochemical process is beautifully captured through this molecular model artwork. It serves as a powerful reminder of how proteins like p53 interact with genetic material at various levels - from secondary structures all the way up to quaternary structures. Overall, this stunning visual representation underscores the essential role played by tumour suppressor proteins like p53 in preventing cancerous growth and highlights their potential therapeutic applications in combating malignancies.

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