Sirtuin enzyme and p53, artwork C017 / 3659

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Sirtuin enzyme and p53, artwork C017 / 3659

Sirtuin enzyme and p53. Computer artwork of a sirtuin (Sir2) enzyme (pink) bound to a p53 peptide (orange). Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases that are required for diverse biological processes, including transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilisation, and lifespan regulation. NAD is shown as a stick model (centre). p53 is crucial in multicellular organisms, where it regulates the cell cycle (the means by which cells replicate) and prevents the proliferation of cells with damaged DNA

Science Photo Library features Science and Medical images including photos and illustrations

Media ID 9341245

© RAMON ANDRADE 3DCIENCIA/SCIENCE PHOTO LIBRARY

Binding Bound Cell Cycle Complex Complexed Metabolic Metabolism Peptide Preventative Prevention Proteins Proteomics Regulation Regulator Secondary Structure Tertiary Structure Tumor Suppressor Tumour Suppressor Protein Biochemical Biochemistry Molecular Model Protein

EDITORS COMMENTS
This artwork, titled "Sirtuin enzyme and p53" beautifully captures the intricate relationship between a sirtuin (Sir2) enzyme and a p53 peptide. The vibrant pink hue of the Sir2 enzyme contrasts strikingly with the orange color of the p53 peptide, creating an eye-catching visual representation. The Sir2 enzymes belong to a unique class of NAD (+)-dependent deacetylases that play crucial roles in various biological processes. This includes transcriptional silencing, regulation of apoptosis (programmed cell death), fat mobilization, and lifespan regulation. In this artwork, we witness the binding of the Sir2 enzyme to the p53 peptide, highlighting their complex interaction. The significance of this interaction lies in its impact on multicellular organisms. The p53 protein acts as a tumor suppressor by regulating the cell cycle and preventing damaged DNA from proliferating. By forming a complex with Sir2 enzymes, it adds another layer to its role as a preventative measure against tumorigenesis. Notably depicted in this illustration is NAD represented as stick models at the center stage. This molecule serves as an essential component for both Sir2 enzymes' activity and cellular metabolism. Ramon Andrade's artistic portrayal masterfully combines scientific accuracy with aesthetic appeal. Through this print, viewers are invited into the fascinating world of biochemical regulators and molecular interactions that underpin fundamental biological processes within our cells.

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