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Multiple sclerosis, SEM
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Multiple sclerosis, SEM
Multiple sclerosis. Coloured scanning electron micrograph (SEM) of microglial cells (round) ingesting oligodendrocytes (branched). This is the process thought to occur in multiple sclerosis (MS). Oligodendrocytes form insulating myelin sheaths around nerve axons in the central nervous system. Microglia normally ingest cell debris and bacteria as part of the bodys immune response. In MS they attack oligodendrocytes, possibly triggered by a virus in people with hereditary susceptibility. Destruction of myelin sheaths leads to loss of nerve function. Symptoms include unsteady gait, visual and speech defects and paralysis. Magnification: x1200 when 10cm wide
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6414926
© DR JOHN ZAJICEK/SCIENCE PHOTO LIBRARY
Central Nervous System Cytological Cytology Degenerative Demyelination Ingesting Macrophage Microglia Multiple Sclerosis Myelin Sheath Neural Oligodendrocyte Oligodendrocytes Pathological Pathology Phagocyte Phagocytic Phagocytosis Abnormal Cells Condition Disorder Ingestion Neurological Neurology Unhealthy
EDITORS COMMENTS
This print from Science Photo Library provides a close-up view of the intricate process occurring in multiple sclerosis (MS). The image showcases the colored scanning electron micrograph (SEM) of microglial cells, round in shape, as they engulf and ingest oligodendrocytes that appear branched. In MS, this very process is believed to take place, where microglia attack oligodendrocytes instead of their usual role of clearing cell debris and bacteria. Oligodendrocytes play a crucial role in forming insulating myelin sheaths around nerve axons within the central nervous system. However, when these myelin sheaths are destroyed due to MS, it leads to a loss of nerve function. This debilitating condition manifests through various symptoms such as unsteady gait, visual and speech defects, and even paralysis. The development of MS may be triggered by a virus in individuals with hereditary susceptibility. This SEM image sheds light on the pathological aspect of MS by showcasing how microglial cells target oligodendrocytes for ingestion rather than protecting them. With its vibrant green hues highlighting the abnormality within neural cells affected by this degenerative disease, this photograph serves as both an educational tool for medical professionals studying neurology and cytology while also raising awareness about multiple sclerosis among the general public.
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