Enzyme catalysing DNA recombination C016 / 0725
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Enzyme catalysing DNA recombination C016 / 0725
Enzyme catalysing DNA recombination. Molecular model of the enzyme CRE (cyclization recombination) recombinase (blue and green) mediating the recombination of strands of DNA (deoxyribonucleic acid, purple) at a Holliday Junction. This recombination is a natural genetic process known as crossing over, and involves the mixing of two strands of DNA. Recombinase enzymes snip open each DNA strand, starting the process going and forming a four-way alignment known as a Holliday Junction. It is this structure that other recombinases, like CRE, attach to as they continue the process
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Media ID 9214715
© LAGUNA DESIGN/SCIENCE PHOTO LIBRARY
Catalysing Cre Recombinase Cross Over Crossing Over Crossover Cyclization Recombination Double Helix Enzyme Genetic Genetic Diversity Helices Holliday Junction Homologous Chromosomes Homologous Recombination Mediating Mixing Nucleic Acid Proteins Proteomics Recombination Recombining Strand Strands Sugar Phosphate Backbone Biochemical Biochemistry Deoxyribonucleic Acid Genetics Molecular Molecular Model Protein
EDITORS COMMENTS
This print showcases the intricate process of enzyme catalysing DNA recombination. The molecular model of the enzyme CRE recombinase, represented in shades of blue and green, takes center stage as it mediates the recombination of strands of DNA. The purple strands symbolize deoxyribonucleic acid (DNA), which undergoes a natural genetic process called crossing over. In this image, we witness the mixing of two strands of DNA through the action of recombinase enzymes that snip open each strand to initiate the process. This results in a four-way alignment known as a Holliday Junction, depicted here against a black background. Other recombinases like CRE attach to this structure to continue facilitating recombination. The significance lies in how this biological phenomenon contributes to genetic diversity by combining genetic material from different sources. It is through processes like these that organisms can evolve and adapt to their environment. With its striking visual representation and emphasis on biochemical intricacies, this artwork not only highlights the complexity but also celebrates the beauty found within our own genetic makeup. It serves as a reminder that even at a molecular level, life is constantly evolving and interconnecting in fascinating ways.
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