Gene activator protein
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Gene activator protein
Gene activator protein. Computer artwork of catabolite gene activator protein (CAP, blue and red) bound to a molecule of deoxyribonucleic acid (DNA). CAP is a dimer, a protein made up of 2 identical subunits (red and blue). It activates genes that enable bacteria to use an alternative energy source when glucose, the preferred energy source, is unavailable. Falling levels of glucose cause an increase in the messenger molecule cAMP, which binds to CAP enabling CAP to bind to DNA. cAMP binds at 2 siteS (black) either side of the centre of the CAP molecule. CAP binds to DNA at specific sites, causing it to bend. This enhances the ability of the enzyme RNA polymerase to make mRNA copies of the targeted gene
Science Photo Library features Science and Medical images including photos and illustrations
Media ID 6388273
© DR TIM EVANS/SCIENCE PHOTO LIBRARY
Activating Alternative Bacterial Bacteriology Bending Binding Catabolite Gene Activator Dimer Double Helix Energy Source Genetic Genetic Switch Glucose Helical Lac Operon Molecular Biology Positive Control Regulatory Protein Strand Strands Transcriptional Control Bio Chemistry Biochemical Computer Artwork Deoxyribonucleic Acid Genetics Micro Biology Microbiological Molecular Protein
EDITORS COMMENTS
This print showcases the intricate world of gene regulation through a stunning computer artwork. At its center, we see the catabolite gene activator protein (CAP) in vibrant blue and red, bound to a molecule of deoxyribonucleic acid (DNA). CAP, composed of two identical subunits, plays a crucial role in activating genes that allow bacteria to utilize alternative energy sources when glucose is scarce. As glucose levels decline, the messenger molecule cAMP increases and binds to CAP, enabling it to bind with DNA. The black sites on either side of CAP indicate where cAMP attaches itself. Once attached, CAP causes DNA to bend at specific sites. This bending enhances the activity of RNA polymerase enzyme in creating mRNA copies of targeted genes. The image beautifully captures the complexity and elegance of molecular biology. It highlights how proteins like CAP act as genetic switches by regulating transcriptional control. Through this process, bacteria adapt their metabolic pathways by activating genes necessary for survival under challenging conditions. This remarkable artwork not only provides insight into biochemical processes but also serves as a reminder of nature's ingenuity in finding alternative solutions for energy production when faced with adversity.
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